PPARα Dependent Regulation of Gut Microbiota: Implication for Host Metabolic Homeostasis.

doi:10.1002/mnfr.70549

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Article

PPARα Dependent Regulation of Gut Microbiota: Implication for Host Metabolic Homeostasis.

Molecular nutrition & food research - 1 Jul 2026

Sánchez-Tapia Mónica, Tobón-Cornejo Sandra, Guevara-Cruz Martha, Velázquez-Villegas Laura A, Hernández-Pando Rogelio, López-Barradas Adriana, Guizar-Heredia Rocio, Maya Otoniel, Furuzawa-Carballeda Janette, Rebollar-Vega Rosa, Vargas-Castillo Ariana, Torres Nimbe, Tovar Armando R

Abstract excerpt

The peroxisome proliferator-activated receptor alpha (PPARα) is a key regulator of lipid metabolism and energy homeostasis. However, its role in shaping the gut microbiota requires further investigation. Therefore, the aim of the present study was to investigate whether the lack of PPARα in a mouse model or the presence of a single nucleotide polymorphism (SNP) rs6008259 of PPARα in humans can modulate the gut...

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PMID: 42441528
DOI: 10.1002/mnfr.70549
PMCID: PMC13362006

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