Article
D2 dopamine receptors stimulate mitogenesis through pertussis toxin-sensitive G proteins and Ras-involved ERK and SAP/JNK pathways in rat C6-D2L glioma cells.
Journal of neurochemistry - 1 Sept 1998
Luo Y, Kokkonen G C, Wang X, Neve K A, Roth G S
Abstract excerpt
Dopamine D2 receptors are members of the G protein-coupled receptor superfamily and are expressed on both neurons and astrocytes. Using rat C6 glioma cells stably expressing the rat D2L receptor, we show here that dopamine (DA) can activate both the extracellular signal-regulated kinase (ERK) and...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Dopamine
- Enzyme Activation
- Flavonoids
- GTP-Binding Proteins
- GTPase-Activating Proteins
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinases
- Mitosis
- Mutation
- Pertussis Toxin
- Proteins
- Rats
- Receptors, Dopamine D2
- Recombinant Proteins
- Thymidine
- Tumor Cells, Cultured