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Article

Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2.

Journal of cellular physiology - 1 Jan 2007

Jackson Rebecca A, Murali Sadasivam, van Wijnen Andre J, Stein Gary S, Nurcombe Victor, Cool Simon M

Abstract excerpt

The transcription factor Runx2 can be controlled by a number of upstream regulators involved in intracellular signalling, including the activation ERK1/2 signaling by fibroblast growth factor-2 (FGF-2). FGFs interact with their cell surface receptors (FGFRs) through an obligate cross-binding interaction with heparan sulfate proteoglycan (HSPG) co-receptors; exogenous HS sugar chains have been shown to potently...

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PMID: 17051597
DOI: 10.1002/jcp.20813

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FGFR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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