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Article

The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates.

The Journal of biological chemistry - 29 Sept 2000

Nurcombe V, Smart C E, Chipperfield H, Cool S M, Boilly B, Hondermarck H

Abstract excerpt

To explore how heparan sulfate (HS) controls the responsiveness of the breast cancer cell lines MCF-7 and MDA-MB-231 to fibroblast growth factors (FGFs), we have exposed them to HS preparations known to have specificity for FGF-1 (HS glycosaminoglycan (HSGAG A)) or FGF-2 (HSGAGB). Proliferation assays confirmed that MCF-7 cells were highly responsive to FGF-2 complexed with GAGB, whereas migration assays...

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Identifiers

PMID: 10862617
DOI: 10.1074/jbc.M003038200

Genes

FGFR1
FGFR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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