Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability and evolution of two pharmacologically important classes of genes.

Pharmacogenomics - 1 Jan 2004

Pungliya Manish S, Salisbury Benjamin A, Nandabalan Krishnan, Stephens J Claiborne

Abstract excerpt

We have studied the human genetic variability of single nucleotide polymorphisms (SNPs) and haplotypes in two pharmaceutically important classes of genes that might be expected to experience different evolutionary pressures: antigen presentation and processing (APP) and nuclear hormone receptor (NHR) genes. We compared the variation pattern in these two classes of genes with 5119 reference (REF) genes. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Antigen Presentation
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APP gene

Share to Gene Frequency

Share to Hominidae

Share to Polymorphism, Single Nucleotide

Share to Receptors, Cytoplasmic and Nuclear

Source

Identifiers

PMID: 14683423
DOI: 10.1517/phgs.5.1.115.25684

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability and evolution of two pharmacologically important classes of genes.PMID 14683423Read ↗

Selected neuropeptide genes show genetic differentiation between Africans and non-Africans.Semantic proximity Read ↗

Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response.Semantic proximity Read ↗

SNP alleles in human disease and evolution.Semantic proximity Read ↗

Human-chimpanzee DNA sequence variation in the four major genes of the renin angiotensin system.Semantic proximity Read ↗

Dichotomy of single-nucleotide polymorphism haplotypes in olfactory receptor genes and pseudogenes.Semantic proximity Read ↗

Heterospecific SNP diversity in humans and rhesus macaque (Macaca mulatta).Semantic proximity Read ↗

Beyond drugs: the evolution of genes involved in human response to medicationsSemantic proximity Read ↗

Differential genomic architecture of a ligand-receptor pair in humans and commonly used model organismsSemantic proximity Read ↗

Global Survey of Variation in a Human Olfactory Receptor Gene Reveals Signatures of Non-Neutral Evolution.Semantic proximity Read ↗

Gene and protein domain-specific patterns of genetic variability within the G-protein coupled receptor superfamily.Semantic proximity Read ↗

Large-scale polymorphism discovery in macaque G-protein coupled receptors.Semantic proximity Read ↗

Catalog of 178 variations in the Japanese population among eight human genes encoding G protein-coupled receptors (GPCRs).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.