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Beyond drugs: the evolution of genes involved in human response to medications

23 Oct 2019

Abstract excerpt

The genetic variation of our species reflects human demographic history and adaptation to diverse local environments. Part of this genetic variation affects individual responses to exogenous substances, such as food, pollutants and drugs, and plays an important role in drug efficacy and safety. This review provides a synthesis of the evolution of loci implicated in human pharmacological response and metabolism,...

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Identifiers

PMID: 31640517
DOI: 10.1098/rspb.2019.1716

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