Article
The 1239G/C polymorphism in exon 5 of BACE1 gene may be associated with sporadic Alzheimer's disease in Chinese Hans.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2004
Shi Jiajun, Zhang Sizhong, Tang Mouni, Liu Xiehe, Li Tao, Wang Yingcheng, Han Haiying, Guo Yangbo, Hao Yuantao, Zheng Keqin, Kong Xiangdong, Su Zhiguang, Tong Yu, Ma Cui
Abstract excerpt
Beta-site amyloid-precursor protein cleaving enzyme (BACE1) is a candidate risk factor for Alzheimer's disease (AD) because of involving in generating beta-amyloid peptide, which is thought to play a central role in the pathogenesis of the disease. A single nucleotide polymorphism 1239G/C in exon 5 of BACE1 gene and a weak association between this polymorphism and AD in Caucasian APOEepsilon4 allele carriers has...
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