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Article

Glutathione S transferase theta 1 gene (GSTT1) null genotype is associated with an increased risk for acquired aplastic anemia in children.

Pediatric research - 1 Mar 2004

Dirksen Uta, Moghadam Kaveh Asadi, Mambetova Chinara, Esser Charlotte, Fuhrer Monika, Burdach Stefan

Abstract excerpt

Two main factors have been implicated in the mechanism underlying the pathogenesis of acquired aplastic anemia: environmental factors and genetic susceptibility. Individuals vary in their ability to metabolize several DNA-damaging agents due to polymorphisms of biotransforming enzymes. Genetically determined differences in the expression of these enzymes could explain interindividual risks in developing acquired...

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Share to Anemia, Aplastic
Share to Cytochrome P-450 CYP2E1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14681495
DOI: 10.1203/01.PDR.0000111201.56182.FE

Genes

GSTT1
GSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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