Article
Genetic polymorphisms of CYP3A4, GSTT1, GSTM1, GSTP1 and NQO1 and the risk of acquired idiopathic aplastic anemia in Caucasian patients.
Haematologica - 1 Aug 2005
Dufour Carlo, Svahn Johanna, Bacigalupo Andrea, Longoni Daniela, Varotto Stefania, Iori Anna Paola, Bagnasco Francesca, Locasciulli Anna, Menna Giuseppe, Ramenghi Ugo, Lanciotti Marina
Abstract excerpt
BACKGROUND AND OBJECTIVES: Various drugs and xenobiotics are involved in the pathogenesis of acquired aplastic anemia. Their harmful potential depends on the amount of exposure to them and on the detoxifying capacity of the recipient. Genetic polymorphisms of some important detoxifying enzymes are associated with low or absent cata-lytic activity of the protein. We assessed whether, in a Caucasian population, low...
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