Cell Cycle Checkpoint Function in Bladder Cancer

doi:10.1093/jnci/djg120

Article

Cell Cycle Checkpoint Function in Bladder Cancer

16 Dec 2003

Abstract excerpt

BACKGROUND: Cell cycle checkpoints function to maintain genetic stability by providing additional time for repair of DNA damage and completion of events that are necessary for accurate cell division. Some checkpoints, such as the DNA damage G1 checkpoint, are dependent on p53, whereas other checkpoints, such as the decatenation G(2) checkpoint, are not. Because bladder transitional cell carcinomas (TCCs) often...

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