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Article

The human decatenation checkpoint

2 Oct 2001

Abstract excerpt

Chromatid catenation is actively monitored in human cells, with progression from G(2) to mitosis being inhibited when chromatids are insufficiently decatenated. Mitotic delay was quantified in normal and checkpoint-deficient human cells during treatment with ICRF-193, a topoisomerase II catalytic inhibitor that prevents chromatid decatenation without producing topoisomerase-associated DNA strand breaks. Ataxia...

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PMID: 11593014
DOI: 10.1073/pnas.221430898

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