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Article

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

Journal of the National Cancer Institute - 17 Jul 1996

Wang Q, Fan S, Eastman A, Worland P J, Sausville E A, O'Connor P M

Abstract excerpt

BACKGROUND: Arrest of the cell cycle in G2 phase following DNA damage helps protect cell viability by allowing time for DNA repair before entry into mitosis (M phase). Abrogation of G2 arrest sensitizes cells to the effects of DNA-damaging agents. UCN-01 (7-hydroxystaurosporine), a protein kinase C inhibitor that may block G2 checkpoint regulation, has been reported to enhance the cytotoxicity of mitomycin C, a...

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Source

Identifiers

PMID: 8667426
DOI: 10.1093/jnci/88.14.956

Genes

UCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.PMID 8667426Read ↗

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogationSemantic proximity Read ↗

Molecular Basis for G2 Arrest Induced by 2′- C -Cyano-2′-Deoxy-1-β- d - Arabino -Pentofuranosylcytosine and Consequences of Checkpoint AbrogationSemantic proximity Read ↗

[Abrogation effect of UCN-01 on radiation-induced G2 phase arrest of tumor cells and its mechanism].Semantic proximity Read ↗

Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.Semantic proximity Read ↗

A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.Semantic proximity Read ↗

Breaching the DNA damage checkpoint via PF-00477736, a novel small-molecule inhibitor of checkpoint kinase 1Semantic proximity Read ↗

7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines.Semantic proximity Read ↗

Abrogation of the G2 Checkpoint by Inhibition of Wee-1 Kinase Results in Sensitization of p53-Deficient Tumor Cells to DNA-Damaging AgentsSemantic proximity Read ↗

p53‐dependent G1 arrest in 1st or 2nd cell cycle may protect human cancer cells from cell death after treatment with ionizing radiation and Chk1 inhibitorsSemantic proximity Read ↗

AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies.Semantic proximity Read ↗

Cell Cycle Checkpoint Function in Bladder CancerSemantic proximity Read ↗

[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line].Semantic proximity Read ↗

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