Article
Unmasking cryptic epitopes after loss of immunodominant tumor antigen expression through epitope spreading.
International journal of cancer - 1 Sept 2001
Lally K M, Mocellin S, Ohnmacht G A, Nielsen M B, Bettinotti M, Panelli M C, Monsurro V, Marincola F M
Abstract excerpt
The basis of intra-tumoral and systemic T cell reactivity toward cancer remains unclear. In particular the role that peripheral stimuli, whether endogenous or exogenous, play in shaping acquired immune response toward cancer remains poorly understood. In this study we document the surfacing of systemic immune reactivity toward a cryptic epitope from the MAGE-12 gene (MAGE-12:170-178), after temporary regression...
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