Article
Tumor-associated carbohydrate antigens: a possible avenue for cancer prevention.
Immunology and cell biology - 1 Aug 2005
Xu Yanfei, Sette Alessandro, Sidney John, Gendler Sandra J, Franco Alessandra
Abstract excerpt
Here we examine the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as potential preventive vaccines for carcinomas. Our recent results suggest that CD8+ T cells (CTL) are capable of recognizing TACA in a conventional class I MHC-restricted fashion. The ThomsenFriedenreich antigen (TF), a disaccharide, and Tn, its immediate precursor, are TACA largely expressed in carcinomas. TF and...
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