Article
[Ataxia telangiectasia: what impact in clinical oncology?].
Bulletin du cancer - 1 Jan 1992
Stoppa-Lyonnet D, Aurias A
Abstract excerpt
Ataxia telangiectasia (AT) is a hereditary disease transmitted in a recessive mode and characterized by chromosomal instability and radiosensitivity. AT patients have a 100-fold higher risk of cancer than the general population. Although AT is a rare disease of which the frequency has been estimated to be 1/40,000, the frequency of the heterozygosity status, when assessed with the Hardy-Weinberg equation is high...
Topics
- Ataxia Telangiectasia
- Breast Neoplasms
- Causality
- Chromosome Fragility
- Female
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Male
- Neoplasms