Article
Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer.
Cancer genetics and cytogenetics - 1 Dec 1996
Athma P, Rappaport R, Swift M
Abstract excerpt
About 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurologic syndrome in which cancer incidence of homozygotes is approximately 100-fold greater than the general population's rates. The hypothesis that A-T...
Topics
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Ataxia Telangiectasia
- Breast Neoplasms
- DNA
- Female
- Genetic Carrier Screening
- Genetic Markers
- Genetic Predisposition to Disease
- Genotype
- Homozygote
- Humans
- Incidence
- Middle Aged
- Odds Ratio
- Recombination, Genetic