Article
Molecular genotyping shows that ataxia-telangiectasia heterozygotes are predisposed to breast cancer.
Cancer genetics and cytogenetics - 1 Dec 1996
Athma P, Rappaport R, Swift M
Abstract excerpt
About 1.4% of the general population are heterozygous carriers of the gene for ataxiatelangiectasia (A-T), an autosomal recessive progressive neurologic syndrome in which cancer incidence of homozygotes is approximately 100-fold greater than the general population's rates. The hypothesis that A-T heterozygotes are predisposed to breast cancer was tested by the unbiased statistically powerful index-test method...
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