Article
Cancer risk in heterozygotes for ataxia-telangiectasia.
International journal of cancer - 15 Jul 2001
Geoffroy-Perez B, Janin N, Ossian K, Laugé A, Croquette M F, Griscelli C, Debré M, Bressac-de-Paillerets B, Aurias A, Stoppa-Lyonnet D, Andrieu N
Abstract excerpt
Epidemiological studies have suggested that ataxia-telangiectasia (AT) heterozygotes have a predisposition to cancer, especially breast cancer in women. Now, haplotyping can identify heterozygotes for AT mutation (ATM) in AT families, allowing the risk of cancer associated with ATM heterozygosity status to be better assessed. We report a family study of AT patients, in which we estimated the risk of cancer...
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