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Article

Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex.

Development genes and evolution - 1 Jan 2004

Hediger Monika, Burghardt Géza, Siegenthaler Christina, Buser Nathalie, Hilfiker-Kleiner Denise, Dübendorfer Andreas, Bopp Daniel

Abstract excerpt

Sex-determining cascades are supposed to have evolved in a retrograde manner from bottom to top. Wilkins' 1995 hypothesis finds support from our comparative studies in Drosophila melanogaster and Musca domestica, two dipteran species that separated some 120 million years ago. The sex-determining cascades in these flies differ at the level of the primary sex-determining signal and their targets, Sxl in Drosophila...

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Identifiers

PMID: 14673649
DOI: 10.1007/s00427-003-0372-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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