Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transformer2 gene in Musca domestica is required for selecting and maintaining the female pathway of development.

Development genes and evolution - 1 Apr 2005

Burghardt Géza, Hediger Monika, Siegenthaler Christina, Moser Martin, Dübendorfer Andreas, Bopp Daniel

Abstract excerpt

We present the isolation and functional analysis of a transformer2 homologue Mdtra2 in the housefly Musca domestica. Compromising the activity of this gene by injecting dsRNA into embryos causes complete sex reversal of genotypically female individuals into fertile males, revealing an essential function of Mdtra2 in female development of the housefly. Mdtra2 is required for female-specific splicing of Musca...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disorders of Sex Development
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Regulator

Share to Houseflies

Share to Insect Proteins

Share to Microinjections

Share to Ribonucleoproteins

Share to Sex Determination Processes

Source

Identifiers

PMID: 15662529
DOI: 10.1007/s00427-004-0464-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transformer2 gene in Musca domestica is required for selecting and maintaining the female pathway of development.PMID 15662529Read ↗

Molecular characterization of the key switch F provides a basis for understanding the rapid divergence of the sex-determining pathway in the housefly.Semantic proximity Read ↗

Sex determination in Drosophila melanogaster and Musca domestica converges at the level of the terminal regulator doublesex.Semantic proximity Read ↗

Sex determination in the Drosophila germline is dictated by the sexual identity of the surrounding soma.Semantic proximity Read ↗

The mutation masculinizer (man) defines a sex-determining gene with maternal and zygotic functions in Musca domestica L.Semantic proximity Read ↗

Genetic control of courtship behavior in the housefly: evidence for a conserved bifurcation of the sex-determining pathway.Semantic proximity Read ↗

Hemimetabolous insects elucidate the origin of sexual development via alternative splicingSemantic proximity Read ↗

Drosophila melanogaster male somatic cells feminized solely by TraF can collaborate with female germ cells to make functional eggs.Semantic proximity Read ↗

Developmental analysis of two sex-determining genes, M and F, in the housefly, Musca domestica.Semantic proximity Read ↗

Genetic control of sex determination in the germ line and soma of the housefly, Musca domestica.Semantic proximity Read ↗

Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.Semantic proximity Read ↗

The female-determining gene F of the housefly, Musca domestica, acts maternally to regulate its own zygotic activity.Semantic proximity Read ↗

Transcriptome Differences between Alternative Sex Determining Genotypes in the House Fly, Musca domestica.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.