Article
Analysis of the functional relationship between V3 loop and gp120 context with regard to human immunodeficiency virus coreceptor usage using naturally selected sequences and different viral backbones.
Virology - 15 Mar 2003
Bagnarelli Patrizia, Fiorelli Lara, Vecchi Manuela, Monachetti Alessia, Menzo Stefano, Clementi Massimo
Abstract excerpt
The human immunodeficiency virus type 1 (HIV-1) gp120 V3 loop plays a predominant role in chemokine receptor usage; however, other linear and nonlinear gp120 domains are involved in this step of the HIV-1 replication cycle. At present, the functional relationship between V3 and these domains with regard to coreceptor usage is unclear. To gain insights into the nature of this relationship in naturally selected...
Topics
- Amino Acid Sequence
- Cell Line
- HIV Envelope Protein gp120
- HIV-1
- Humans
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Receptors, Chemokine
- Receptors, HIV
- Recombination, Genetic
- Structure-Activity Relationship