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Article

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 May 2007

Adachi Hiroaki, Waza Masahiro, Tokui Keisuke, Katsuno Masahisa, Minamiyama Makoto, Tanaka Fumiaki, Doyu Manabu, Sobue Gen

Abstract excerpt

Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine tract within the androgen receptor (AR). The pathologic features of SBMA are motor neuron loss in the spinal cord and brainstem and diffuse nuclear accumulation and nuclear inclusions of the mutant AR in the residual motor neurons and certain visceral organs. Many components of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17494697
DOI: 10.1523/JNEUROSCI.1242-07.2007
PMCID: PMC6672370

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