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Article

ABCA1 increases extracellular ATP to mediate cholesterol efflux to ApoA-I.

American journal of physiology. Cell physiology - 1 Oct 2011

Lee Jee Yeon, Karwatsky Joel, Ma Loretta, Zha Xiaohui

Abstract excerpt

ATP-binding cassette protein A1 (ABCA1) is a key plasma membrane protein required for the efflux of cellular cholesterol to extracellular acceptors, particularly to apolipoprotein A-I (apoA-I). This process is essential to maintain cholesterol homeostasis in the body. The detailed molecular mechanisms, however, are still insufficiently understood. Also, the molecular identity of ABCA1, i.e., channel, pump, or...

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Source

Identifiers

PMID: 21697542
DOI: 10.1152/ajpcell.00042.2011

Genes

ABCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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