Article
Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells.
Genesis (New York, N.Y. : 2000) - 1 Dec 2003
Tsai Ting-Fen, Bressler Jan, Jiang Yong-Hui, Beaudet Arthur L
Abstract excerpt
In gene targeting studies of the Prader-Willi syndrome (PWS)/Angelman syndrome (AS) domain in mouse ES cells, we recovered only recombinants with the paternal allele for constructs at exons 2 or 3 of the imprinted, maternally silenced Snurf-Snrpn gene. These sites lie close to the imprinting center (IC) for this domain. In contrast, recombinants for Ube3a within the same imprinted domain were recovered with equal...
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