Article
Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.
PLoS genetics - 1 Dec 2011
Smith Emily Y, Futtner Christopher R, Chamberlain Stormy J, Johnstone Karen A, Resnick James L
Abstract excerpt
The Prader-Willi syndrome (PWS [MIM 17620]) and Angelman syndrome (AS [MIM 105830]) locus is controlled by a bipartite imprinting center (IC) consisting of the PWS-IC and the AS-IC. The most widely accepted model of IC function proposes that the PWS-IC activates gene expression from the paternal allele, while the AS-IC acts to epigenetically inactivate the PWS-IC on the maternal allele, thus silencing the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.