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Article

The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice.

Nature genetics - 1 Jul 2001

Bressler J, Tsai T F, Wu M Y, Tsai S F, Ramirez M A, Armstrong D, Beaudet A L

Abstract excerpt

In mice and humans, the locus encoding the gene for small nuclear ribonucleoprotein N (SNRPN/Snrpn), as well as other loci in the region are subject to genomic imprinting. The SNRPN promoter is embedded in a maternally methylated CpG island, is expressed only from the paternal chromosome and lies within an imprinting center that is required for switching to and/or maintenance of the paternal epigenotype. We show...

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Share to Angelman Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11431693
DOI: 10.1038/90067

Genes

SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SNRPN promoter is not required for genomic imprinting of the Prader-Willi/Angelman domain in mice.PMID 11431693Read ↗

A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center.Semantic proximity Read ↗

Structure and function correlations at the imprinted mouse Snrpn locus.Semantic proximity Read ↗

Structure of the imprinted mouse Snrpn gene and establishment of its parental-specific methylation pattern.Semantic proximity Read ↗

Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader–Willi syndrome regionSemantic proximity Read ↗

De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a paternal to maternal imprint switchSemantic proximity Read ↗

The imprinting box of the Prader-Willi/Angelman syndrome domain.Semantic proximity Read ↗

Maternal imprinting of human SNRPN, a gene deleted in Prader-Willi syndrome.Semantic proximity Read ↗

Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells.Semantic proximity Read ↗

Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.Semantic proximity Read ↗

Paternal deletion from Snrpn to Ube3a in the mouse causes hypotonia, growth retardation and partial lethality and provides evidence for a gene contributing to Prader-Willi syndrome.Semantic proximity Read ↗

A novel deletion of SNURF/SNRPN exon 1 in a patient with Prader-Willi-like phenotype.Semantic proximity Read ↗

Small nuclear ribonucleoprotein polypeptide N (SNRPN), an expressed gene in the Prader-Willi syndrome critical region.Semantic proximity Read ↗

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