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Article

Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice.

Biochimica et biophysica acta - 1 Sept 2012

Cheon Yewon, Kim Hyung-Wook, Igarashi Miki, Modi Hiren R, Chang Lisa, Ma Kaizong, Greenstein Deanna, Wohltmann Mary, Turk John, Rapoport Stanley I, Taha Ameer Y

Abstract excerpt

Calcium-independent phospholipase A(2) group VIA (iPLA(2)β) releases docosahexaenoic acid (DHA) from phospholipids in vitro. Mutations in the iPLA(2)β gene, PLA2G6, are associated with dystonia-parkinsonism and infantile neuroaxonal dystrophy. To understand the role of iPLA(2)β in brain, we applied our in vivo kinetic method using radiolabeled DHA in 4 to 5-month-old wild type (iPLA(2)β(+/+)) and knockout...

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PMID: 22349267
DOI: 10.1016/j.bbalip.2012.02.003
PMCID: PMC3393806

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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