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Article

Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila.

The Journal of biological chemistry - 27 Feb 2004

Broderick Kate E, Kean Laura, Dow Julian A T, Pyne Nigel J, Davies Shireen A

Abstract excerpt

cGMP signaling regulates epithelial fluid transport by Drosophila Malpighian (renal) tubules. In order to directly evaluate the importance of cGMP-degrading phosphodiesterases (PDEs) in epithelial transport, bovine PDE5 (a bona fide cGMP-PDE), was ectopically expressed in vivo. Transgenic UAS-PDE5 Drosophila were generated, and PDE5 expression was driven in specified tubule cells in vivo by cell-specific GAL4...

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PMID: 14662775
DOI: 10.1074/jbc.M304679200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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