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Article

The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase.

The Journal of experimental biology - 1 Jul 2004

MacPherson Matthew R, Broderick Kate E, Graham Shirley, Day Jonathan P, Houslay Miles D, Dow Julian A T, Davies Shireen A

Abstract excerpt

Fluid transport in Drosophila melanogaster tubules is regulated by guanosine 3',5'-cyclic monophosphate (cGMP) signalling. Here we compare the functional effects on tubules of different alleles of the dg2 (foraging or for) gene encoding a cGMP-dependent protein kinase (cGK), and show that the fors allele confers an epithelial phenotype. This manifests itself as hypersensitivity of epithelial fluid transport to...

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Identifiers

PMID: 15235005
DOI: 10.1242/jeb.01086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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