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Article

Interaction of catechol and non-catechol substrates with externally or internally facing dopamine transporters.

Journal of neurochemistry - 1 May 2009

Liang Ying-Jian, Zhen Juan, Chen Nianhang, Reith Maarten E A

Abstract excerpt

Our previous work suggested that collapsing the Na(+) gradient and membrane potential converts the dopamine (DA) transporter (DAT) to an inward-facing conformation with a different substrate binding profile. Here, DAT expressing human embryonic kidney 293 cells were permeabilized with digitonin, disrupting ion/voltage gradients and allowing passage of DAT substrates. The potency of p-tyramine and other...

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Identifiers

PMID: 19519772
DOI: 10.1111/j.1471-4159.2009.06034.x
PMCID: PMC2696066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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