Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CYP1A2 activity is an important determinant of clozapine dosage in schizophrenic patients.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Dec 2003

Doude van Troostwijk Lous J A E, Koopmans Richard P, Vermeulen Hans D B, Guchelaar Henk-Jan

Abstract excerpt

Clozapine is an effective atypical antipsychotic drug applied in the treatment of resistant schizophrenia. The drug is mainly metabolized by cytochrome P-450 (CYP) enzymes especially the isozyme CYP1A2. Remarkably, the effective dosage varies widely among patients, making it necessary to individualize drug therapy with clozapine. The explanation for dosage variation may be differences in drug metabolism, and more...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antipsychotic Agents
Share to Caffeine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clozapine

Share to Cytochrome P-450 CYP1A2

Share to Phosphodiesterase Inhibitors

Share to Psychiatric Status Rating Scales

Share to Schizophrenia

Share to Xanthines

Source

Identifiers

PMID: 14659489
DOI: 10.1016/j.ejps.2003.09.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CYP1A2 activity is an important determinant of clozapine dosage in schizophrenic patients.PMID 14659489Read ↗

Impact of CYP1A2 genetic polymorphisms on pharmacokinetics of antipsychotic drugs: a systematic review and meta-analysis.Semantic proximity Read ↗

Correlation between assessment of cytochrome P450 1A2 activity and enzyme activity scores, and their relation to clozapine exposure.Semantic proximity Read ↗

Population pharmacokinetic analysis of mirtazapine.Semantic proximity Read ↗

Clinical and genetic influencing factors on clozapine pharmacokinetics in Tunisian schizophrenic patients.Semantic proximity Read ↗

Factors affecting interindividual differences in clozapine response: a review and case reportSemantic proximity Read ↗

Potential Role of Patients' CYP3A-Status in Clozapine Pharmacokinetics.Semantic proximity Read ↗

The effect of smoking and cytochrome P450 CYP1A2 genetic polymorphism on clozapine clearance and dose requirement.Semantic proximity Read ↗

The Potential Role of POR*28 and CYP1A2*F Genetic Variations and Lifestyle Factors on Clozapine and N-DesmethylClozapine Plasma Levels in Schizophrenia Patients.Semantic proximity Read ↗

Genome-wide association analysis to predict optimal antipsychotic dosage in schizophrenia: a pilot study.Semantic proximity Read ↗

Genetic and Clinical Factors Affecting Plasma Clozapine ConcentrationSemantic proximity Read ↗

Candidate gene analysis of pharmacodynamic targets for antipsychotic dosage.Semantic proximity Read ↗

ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.