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Article

Targeting Stat3 with G-Quartet Oligodeoxynucleotides in Human Cancer Cells

1 Nov 2003

Abstract excerpt

Stat3 is an oncogene that is activated in many human cancer cells. Genetic approaches that disrupt Stat3 activity result in inhibition of cancer cell growth and enhanced cell apoptosis supporting the development of novel drugs targeting Stat3 for cancer therapy. G-quartet oligodeoxynucleotides (ODNs) were demonstrated to be potent inhibitors of Stat3 DNA binding activity in vitro with the G-quartet ODN, T40214,...

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PMID: 14659041
DOI: 10.1089/104454903770946665

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