Article

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3

2023-08-03

Abstract excerpt

<h4>ABSTRACT</h4> Decoy-oligodeoxynucleotides (D-ODNs) can target undruggable transcription factors, such as STAT3. However, challenges in D-ODN delivery and potency hampered their translation. To overcome these limitations, we conjugated STAT3-specific D-ODN to thalidomide (Tha), a known ligand to cereblon (CRBN, a component of E3 ubiquitin ligase) to generate a proteolysis-targeting chimera (STAT3D PROTAC ). S...

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Literature Corpus work: cb2afbaa-0b10-556f-9fb4-9ec4d8329b0f
DOI: 10.1101/2023.08.01.551552

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