Article

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription Factor

2018-04-29

Abstract excerpt

Cyclic STAT3 decoy (CS3D) is a second-generation, double-stranded oligodeoxynucleotide (ODN) that mimics a genomic response element for signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. CS3D competitively inhibits STAT3 binding to target gene promoters, resulting in decreased expression of proteins that promote cellular proliferation and survival. Previous studies have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 00d944af-431f-5382-99e7-a54a63c36a63
DOI: 10.20944/preprints201804.0374.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biochemical Properties of a Decoy Oligodeoxynucleotide Inhibitor of STAT3 Transcription FactorDOI 10.20944/preprints201804.0374.v1Read

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer TherapySemantic proximity Read

Systemic administration of a cyclic signal transducer and activator of transcription 3 (STAT3) decoy oligonucleotide inhibits tumor growth without inducing toxicological effects.Semantic proximity Read

Oligonucleotide-Based Therapeutics for STAT3 Targeting in Cancer—Drug Carriers MatterSemantic proximity Read

Targeting STAT3 in Cancer with Nucleotide TherapeuticsSemantic proximity Read

DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancerSemantic proximity Read

Oligo-PROTAC strategy for cell-selective and targeted degradation of activated STAT3Semantic proximity Read

STAT3 Cyclic Decoy Demonstrates Robust Antitumor Effects in Non-Small Cell Lung Cancer.Semantic proximity Read

Targeting Stat3 in cancer therapySemantic proximity Read

Decoy-PROTAC for specific degradation of “Undruggable” STAT3 transcription factorSemantic proximity Read

A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell lineSemantic proximity Read

STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genesSemantic proximity Read

Safety and efficacy of a STAT3-targeted cyclic oligonucleotide: From murine models to a phase 1 clinical trial in pet cats with oral cancerSemantic proximity Read