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Article

Expression and mutational status of c-kit in small-cell lung cancer: prognostic relevance.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2004

Boldrini Laura, Ursino Silvia, Gisfredi Silvia, Faviana Pinuccia, Donati Valentina, Camacci Tiziano, Lucchi Marco, Mussi Alfredo, Basolo Fulvio, Pingitore Raffaele, Fontanini Gabriella

Abstract excerpt

PURPOSE: The c-kit protein, also known as CD117, is a member of the type III receptor tyrosine kinase family. Kinase activity has been implicated in the pathophysiology of many tumors, including small-cell lung carcinoma (SCLC). Autocrine or paracrine activation of c-kit by its ligand has been postulated for lung cancer, but this receptor can also be activated by mutations of the c-kit gene. We examined c-kit...

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Share to Carcinoma, Small Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunohistochemistry

Share to Lung Neoplasms

Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins c-kit

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Source

Identifiers

PMID: 15217946
DOI: 10.1158/1078-0432.CCR-03-0664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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