Article
Immunohistochemical and mutational analysis of c-kit in gastrointestinal neuroendocrine cell carcinoma.
Japanese journal of clinical oncology - 1 Aug 2006
Ishikubo Tsutomu, Akagi Kiwamu, Kurosumi Masafumi, Yamaguchi Kensei, Fujimoto Takahiro, Sakamoto Hirohiko, Tanaka Yoichi, Ochiai Atsushi
Abstract excerpt
BACKGROUND: Gastrointestinal neuroendocrine cell carcinoma (NEC) is a highly aggressive tumor with poor prognosis, for which an effective therapy is highly desirable. Recently, use of a c-kit inhibitor achieved excellent results against gastrointestinal stromal tumor (GIST) that showed c-kit overexpression and mutation in most cases. According to recent studies, 17-44% of pulmonary NEC also expressed c-kit and...
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