Article
C-kit expression and mutational analysis in medulloblastoma.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000
Chilton-Macneill Susan, Ho Michael, Hawkins Cynthia, Gassas Adam, Zielenska Maria, Baruchel Sylvain
Abstract excerpt
The proto-oncogene c-kit is a receptor tyrosine kinase recognized to initiate essential signal transduction pathways that transmit biological signals for cellular proliferation, differentiation, and metastasis. Aberrant expression or mutation of c-kit has been shown to be involved in the pathogen...
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