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Article

Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003

Varthakavi Vasundhara, Smith Rita M, Bour Stephan P, Strebel Klaus, Spearman Paul

Abstract excerpt

Human cells resist viral infections by a variety of mechanisms. Viruses must overcome host cell restrictions to successfully reproduce their genetic material. Here, we identify a host restriction to viral replication that acts at the stage of particle assembly. Viral protein U (Vpu) is an HIV-1 a...

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Identifiers

PMID: 14657387
DOI: 10.1073/pnas.2433165100
PMCID: PMC299932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14657387-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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