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Article

Changes in susceptibility to posaconazole in clinical isolates of Candida albicans.

The Journal of antimicrobial chemotherapy - 1 Jan 2004

Li Xin, Brown Nathaniel, Chau Andrew S, López-Ribot José L, Ruesga Maria T, Quindos Guillermo, Mendrick Cara A, Hare Roberta S, Loebenberg David, DiDomenico Beth, McNicholas Paul M

Abstract excerpt

OBJECTIVES: To characterize the molecular mechanisms responsible for reduced susceptibility to azoles in Candida albicans clinical isolates. MATERIALS AND METHODS: Seven sequential C. albicans isolates were cultured from an AIDS patient treated with posaconazole for refractory oropharyngeal candidiasis. Expression levels of the CDR1, CDR2 and MDR1 genes, encoding efflux pumps previously implicated in azole...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14657086
DOI: 10.1093/jac/dkh027

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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