Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein.

doi:10.1016/0304-3940(92)90016-z

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Article

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein.

Neuroscience letters - 12 Oct 1992

Hanger D P, Mann D M, Neary D, Anderton B H

Abstract excerpt

The brain tissue from a case of familial Alzheimer's disease (FAD) caused by a missense (valine to glycine) mutation at codon 717 of the amyloid precursor protein (APP) gene has been examined for the presence of abnormally phosphorylated paired helical filament tau (PHF-tau). There was abundant P...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Antibodies, Monoclonal
Blotting, Western
Electrophoresis, Polyacrylamide Gel
Female
Glycine
Humans
Middle Aged
Mutation
Valine
tau Proteins

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