Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spectrum of amyloid beta-protein immunoreactivity in hereditary Alzheimer disease with a guanine to thymine missense change at position 1924 of the APP gene.

Brain research - 31 Jan 1992

Ghetti B, Murrell J, Benson M D, Farlow M R

Abstract excerpt

We studied neuropathologically 3 patients of a previously unreported kindred of presenile Alzheimer disease (AD), characterized by a G to T mutation at base pair 1924 (695 transcript) of the amyloid precursor protein gene. Classic features of presenile AD are observed. Neurofibrillary tangles with paired helical filaments as well as neuritic plaques are found in large number in neocortex and hippocampus....

Topics

Adult
Alzheimer Disease
Amyloid beta-Peptides
Amyloid beta-Protein Precursor
Brain
Female
Genes
Guanine
Humans
Immunohistochemistry
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Thymine

Source

Identifiers

PMID: 1611485
DOI: 10.1016/0006-8993(92)90519-f

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1611485-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spectrum of amyloid beta-protein immunoreactivity in hereditary Alzheimer disease with a guanine to thymine missense change at position 1924 of the APP gene.PMID 1611485Read ↗

Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.Semantic proximity Read ↗

Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-Aβ APP mutation.Semantic proximity Read ↗

Abundance of the longer A beta 42 in neocortical and cerebrovascular amyloid beta deposits in Swedish familial Alzheimer's disease and Down's syndrome.Semantic proximity Read ↗

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.Semantic proximity Read ↗

Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein.Semantic proximity Read ↗

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathySemantic proximity Read ↗

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.Semantic proximity Read ↗

Vascular variant of prion protein cerebral amyloidosis with tau-positive neurofibrillary tangles: the phenotype of the stop codon 145 mutation in PRNP.Semantic proximity Read ↗

Dementia associated with a 216 base pair insertion in the prion protein gene. Clinical and neuropathological features.Semantic proximity Read ↗

Expression of a normal and variant Alzheimer's beta-protein gene in amyloid of hereditary cerebral hemorrhage, Dutch type: DNA and protein diagnostic assays.Semantic proximity Read ↗

A stop-codon mutation in the BRI gene associated with familial British dementia.Semantic proximity Read ↗

Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.