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Article

Familial Alzheimer's disease with the amyloid precursor protein position 717 mutation and sporadic Alzheimer's disease have the same cytoskeletal pathology.

Neuroscience letters - 30 Mar 1992

Lantos P L, Luthert P J, Hanger D, Anderton B H, Mullan M, Rossor M

Abstract excerpt

The cytoskeletal pathology of a patient with familial Alzheimer's disease (AD) associated with the probably causal amyloid precursor protein (APP) codon 717 Val----Ile mutation is described. In addition to moderately extensive beta A4 protein deposition within the substance of the brain and in blood vessel walls (congophilic angiopathy), there was abundant cytoskeletal pathology in the form of neurofibrillary...

Topics

Alzheimer Disease
Amyloid beta-Protein Precursor
Blotting, Western
Brain Chemistry
Cytoskeleton
Humans
Mutation
Neurofilament Proteins
tau Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1584463
DOI: 10.1016/0304-3940(92)90408-y

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1584463-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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