Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val-->Ile mutation in the amyloid precursor protein gene.

doi:10.1016/0197-4580(93)90099-w

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Article

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val-->Ile mutation in the amyloid precursor protein gene.

Neurobiology of aging - 1 Jan 2000

Mullan M, Tsuji S, Miki T, Katsuya T, Naruse S, Kaneko K, Shimizu T, Kojima T, Nakano I, Ogihara T

Abstract excerpt

Alzheimer's disease (AD) is the most common cause of dementia (32). Although the majority of cases of AD are sporadic, the most consistent risk factor detected in several epidemiological studies has been a positive family history of the disease (14,21). In addition, many large pedigrees have been described in which AD appears to be inherited as an autosomal dominant disorder. In one such pedigree (F23) a point...

Topics

Adult
Age of Onset
Aged
Alzheimer Disease
Amyloid beta-Protein Precursor
Brain
Brain Chemistry
Canada
Codon
Down Syndrome
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Isoleucine

Japan

Lewy Bodies

Male

Middle Aged

Mutation

Source

Open in PubMed

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PMID: 8247223
DOI: 10.1016/0197-4580(93)90099-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8247223-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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