Article
Beta A4 protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the beta A4 amyloid precursor protein gene and sporadic Alzheimer's disease.
Neuroscience letters - 12 Jan 1993
Cairns N J, Chadwick A, Lantos P L, Levy R, Rossor M N
Abstract excerpt
Beta A4 protein immunoreactivity in the neocortex and hippocampus of familial Alzheimer's disease (AD) including the case with the beta A4 amyloid precursor protein (APP) gene mutation in codon 717 (APP717 Val-->Ile) and sporadic cases of AD is described. A semi-automatic image analysis system was used to quantify beta A4 protein load in the isocortex of the frontal and temporal lobes and in subfields of the...
Topics
- Aged
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Cerebral Cortex
- Codon
- Hippocampus
- Humans
- Immunohistochemistry
- Middle Aged
- Mutation
- Paraffin Embedding