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Article

DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection.

Annals of neurology - 1 Oct 2011

Wang Zhiquan, Liu Jun, Chen Siyan, Wang Ying, Cao Li, Zhang Yu, Kang Wenyan, Li Hui, Gui Yaxing, Chen Shengdi, Ding Jianqing

Abstract excerpt

OBJECTIVE: Loss of function mutations of Park7/DJ-1 gene increase the susceptibility of dopaminergic cells to reactive oxygen species and cause early onset familial Parkinson disease (PD). However, the mechanisms underlying dopaminergic neuron loss related to DJ-1 mutation remain undefined. Therefore, it is important to find the new mechanisms underlying the antioxidative functions of DJ-1. METHODS: DJ-1...

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Share to Cell Line, Transformed
Share to ets-Domain Protein Elk-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Signaling System

Share to Oncogene Proteins

Share to Protein Deglycase DJ-1

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Share to Superoxide Dismutase

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Source

Identifiers

PMID: 21796667
DOI: 10.1002/ana.22514

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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