Article
Function of RARgamma and RARalpha2 at the initiation of retinoid signaling is essential for avian embryo survival and for distinct events in cardiac morphogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 2003
Romeih Mahmoud, Cui Jian, Michaille Jean-Jacques, Jiang Weihong, Zile Maija H
Abstract excerpt
Avian embryogenesis requires retinoid receptor activation by the vitamin A active form, retinoic acid (RA), during neurulation. We conducted loss-of-function analysis in quail embryos by nutritional deprivation of RA and by blocking generation of retinoid receptors. Here we identify a distinct role for RARalpha2 in cardiac inflow tract morphogenesis and for RARgamma in cardiac left/right orientation and looping...
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