Article
Functional characterization and genetic mapping of alk8.
Mechanisms of development - 1 Feb 2001
Payne T L, Postlethwait J H, Yelick P C
Abstract excerpt
The novel type I TGFbeta family member receptor alk8 is expressed both maternally and zygotically. Functional characterization of alk8 was performed using microinjection studies of constitutively active (CA), kinase modified/dominant negative (DN), and truncated alk8 mRNAs. CA Alk8 expression produces ventralized embryos while DN Alk8 expression results in dorsalized phenotypes. Truncated alk8 expressing embryos...
Topics
- Activin Receptors
- Animals
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins
- Chromosome Mapping
- Conserved Sequence
- Down-Regulation
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Genes, Dominant
- Glycoproteins
- Humans