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Functional characterization and genetic mapping of alk8.

Mechanisms of development - 1 Feb 2001

Payne T L, Postlethwait J H, Yelick P C

Abstract excerpt

The novel type I TGFbeta family member receptor alk8 is expressed both maternally and zygotically. Functional characterization of alk8 was performed using microinjection studies of constitutively active (CA), kinase modified/dominant negative (DN), and truncated alk8 mRNAs. CA Alk8 expression produces ventralized embryos while DN Alk8 expression results in dorsalized phenotypes. Truncated alk8 expressing embryos...

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Identifiers

PMID: 11165484
DOI: 10.1016/s0925-4773(00)00541-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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