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Article

CHEK2 1100delC is not a risk factor for male breast cancer population.

International journal of cancer - 20 Jan 2004

Syrjäkoski Kirsi, Kuukasjärvi Tuula, Auvinen Anssi, Kallioniemi Olli-P

Abstract excerpt

Genetic risk factors for male breast cancer (MBC) are poorly understood. High penetrance genes such as BRCA1 or BRCA2 account for only a small proportion of the disease. A 1100delC mutation in CHEK2 (previously known as CHK2), a cell-cycle checkpoint kinase, has been implicated in predisposition of Li-Fraumeni syndrome (LFS) and breast cancer in families suggestive of LFS. This 1100delC mutation has also been...

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Share to Aged, 80 and over
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14648717
DOI: 10.1002/ijc.11384

Genes

CHEK2
BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CHEK2 1100delC is not a risk factor for male breast cancer population.PMID 14648717Read ↗

CHEK2 1100delC and male breast cancer in the Netherlands.Semantic proximity Read ↗

Analysis of familial male breast cancer for germline mutations in CHEK2.Semantic proximity Read ↗

CHEK2 c.1100delC mutation is associated with an increased risk for male breast cancer in Finnish patient population.Semantic proximity Read ↗

CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

The breast cancer low-penetrance allele 1100delC in the CHEK2 gene is not present in Spanish familial breast cancer population.Semantic proximity Read ↗

Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Absence of the CHEK2 c.1100delC mutation in familial breast and ovarian cancer in Colombia: a case-control studySemantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.Semantic proximity Read ↗

Limited relevance of the CHEK2 gene in hereditary breast cancer.Semantic proximity Read ↗

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