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Article

Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.

Advances in therapy - 1 May 2008

Chen Wang, Yurong Shi, Liansheng Ning

Abstract excerpt

INTRODUCTION: The 1100delC CHEK2 allele has been associated with a 1.4-to 4.7-fold increased risk of breast cancer in women carrying this mutation. Our study investigated the frequency of this allele in a Chinese population. METHODS: Using touchdown polymerase chain reaction, we sequenced the CHE...

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Source

Identifiers

PMID: 18484200
DOI: 10.1007/s12325-008-0057-3

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18484200-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Research trail→

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Breast cancer low-penetrance allele 1100delC in the CHEK2 gene: not present in the Chinese familial breast cancer population.PMID 18484200Read ↗

[CHEK2 c.1100delC may not contribute to genetic background of hereditary breast cancer from Shanghai of China].Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

CHEK2 1100delC variant and breast cancer risk in Caucasians: a meta-analysis based on 25 studies with 29,154 cases and 37,064 controls.Semantic proximity Read ↗

Frequency of the CHEK2 1100delC mutation among women with breast cancer: an international study.Semantic proximity Read ↗

A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients.Semantic proximity Read ↗

The CHEK2 1100delC mutation is not present in Korean patients with breast cancer cases tested for BRCA1 and BRCA2 mutation.Semantic proximity Read ↗

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.Semantic proximity Read ↗

CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia.Semantic proximity Read ↗

Frequency of CHEK2*1100delC in New York breast cancer cases and controls.Semantic proximity Read ↗

Absence of CHEK2*1100delC mutation in families with hereditary breast cancer in North America.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

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