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Article

Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2003

Stancu Mirela, Wu Tsung-Teh, Wallace Charita, Houlihan Patrick S, Hamilton Stanley R, Rashid Asif

Abstract excerpt

Goblet cell carcinoid is a relatively rare neuroendocrine tumor of the vermiform appendix with poorly understood molecular pathogenesis. We studied the clinicopathologic features and genetic alterations, including allelic loss of chromosomes 11q, 16q, and 18q; sequencing of the K-ras, beta-catenin, and DPC4 (SMAD4) genes; and p53 overexpression and loss of DPC4 by immunohistochemistry; in 16 goblet cell...

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PMID: 14681318
DOI: 10.1097/01.MP.0000097362.10330.B1

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SMAD4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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