Article
High levels of latent antithrombin in plasma from patients with antithrombin deficiency.
Thrombosis and haemostasis - 3 May 2017
de la Morena-Barrio María, Sandoval Edna, Llamas Pilar, Wypasek Ewa, Toderici Mara, Navarro-Fernández José, Rodríguez-Alen Agustín, Revilla Nuria, López-Gálvez Raquel, Miñano Antonia, Padilla José, de la Morena-Barrio Belén, Cuesta Jorge, Corral Javier, Vicente Vicente
Abstract excerpt
Antithrombin is an anticoagulant serpin that efficiently inhibits multiple procoagulant proteases. The cost for the structural flexibility required for this function is the vulnerability to mutations that impact its folding pathway. Most conformational mutations identified in serpins cause polymerisation. Only three mutations in SERPINC1 affecting two residues have been found to favour transformation to the...
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